product information
(9Z)-n-(2-(3,4-dihydroxyphenyl)ethyl)-9-octadecenamide
CAS number: 105955-11-1
Groups: All Chemicals
Information:
IUPAC Name: (9Z)-n-(2-(3,4-dihydroxyphenyl)ethyl)-9-octadecenamide

CAS Number: 105955-11-1

Chemical Formula: C26H43NO3

Synonyms: ODA

Product Info: N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain.1↗ Structurally, it is the amide of oleic acid and dopamine and is therefore a “hybrid” analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to the human recombinant VR1 with a Ki of 36 nM making it equipotent to capsaicin and slightly more potent than N-arachidonoyl dopamine in this assay.1↗ It causes hyperalgesia and nocifensive behavior that is blocked by the VR1 antagonist iodo-resiniferatoxin. ODA is selective for VR1 based on observations that it has weak affinity for the rat CB1 receptor (Ki of 1.6 µM) and is a very weak inhibitor of FAAH. ODA is also a potent inhibitor of 5-lipoxygenase from rat basophilic leukemia-1 (RBL-1) cells, with a IC50 of 7.5 nM.
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