product information
(1-Hydroxyethylene)diphosphonic acid
CAS number: 2809-21-4
Groups: Pharmaceutical, Fine & Specialty Chemicals, Oilfield / Mining Chemicals, Water Treatment Chemicals, All Chemicals
Information:
IUPAC Name: (1-hydroxy-1-phosphono-ethyl)phosphonic acid

CAS Number: 2809-21-4

Chemical Formula: C2H8O7P2

Synonyms: (1-Hydroxyethylene) Diphosphonic Acid
(1-Hydroxyethylidene) bis(phosphonic acid)
(1-Hydroxyethylidene) bisphosphonic acid
(1-Hydroxyethylidene) diphoshonic acid
(1-Hydroxyethylidene) diphosphonic acid
(Hydroxyethylidene) diphosphonic acid
1,1,1-Ethanetriol diphosphonate
1-HYDROXY-1,1-DIPHOSPHONOETHANE
1-Hydroxyethane-1, 1-bisphosphonic acid
1-Hydroxyethane-1,1-bisphosphonic acid
1-Hydroxyethane-1,1-diphosphonate
1-Hydroxyethane-1,1-diphosphonic acid
1-Hydroxyethanediphosphonic acid
1-Hydroxyethylidene-1, 1-diphosphonic acid
1-Hydroxyethylidene-1,1-biphosphonate
1-Hydroxyethylidene-1,1-bisphosphonate
1-Hydroxyethylidene-1,1-diphosphonic acid
1000SL
Acetodiphosphonic acid
Acide etidronique [INN-French]
Acido etidronico [INN-Spanish]
Acidum etidronicum [INN-Latin]
C07736
D02373
Dequest 2010
Dequest 2015
Dequest Z 010
Diphosphonate (base)
EHDP
Ethane-1-hydroxy-1, 1-diphosphonate
Ethane-1-hydroxy-1,1-bisphosphonate
Ethane-1-hydroxy-1,1-diphosphonate
Ethane-1-hydroxy-1,1-diphosphonic acid
Etidronic acid (USAN)
Etidronic acid [USAN:BAN:INN]
Ferrofos 510
HEDP
Hydroxyethane-1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
Oxyethylidenediphosphonic acid
Phosphonic acid, (1-hydroxyethylidene) bis-
Phosphonic acid, (1-hydroxyethylidene) di-
Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester
RP 61
Turpinal SL

Product Info: Phosphonates derived from phosphorous (phosphonic) acid are employed in the applications of scale Inhibition, sequestration, dispersion and corrosion inhibition in addition to the main applications of agricultural chemicals such as fertilizers, pesticides, and soil conditioners. Phosphonates offer a wide range of sequestrants to control metal ions in aqueous systems. By forming stable water soluble complexes with multivalent metal ions, phosphonates prevent undesired interaction by blocking normal reactivity of metal ions. This ability contributes to function as threshold industrial water treatment and metal treatment processes (antiscalants, corrosion inhibitors, chelants, sludge conditioners, pulp bleachings, deflocculants, dispersants, metal cleaners, electroplating and crystal growth modifiers). Phosphonates are also used in manufacturing detergents, cosmetics and personal care products for special functions such as low levels iron control, stain removal, bleach stabilization, peroxide stabilization and anti-encrustation. Phosphonates existing in various compounds as acids or salts are marketed in the form of concentrated solutions.

Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as osteoporosis, metastatic disease, and Paget's disease. While bisphosphonates are analogues of endogenous pyrophosphate structurally, they are characterized by a P-C-P bond, the linking oxygen is replaced with a carbon, which is resistant to enzymatic and chemical hydrolysis. General structure is

Bisphosphonate

Side chains are responsible for chemical-physicla properties, mechanism of resorption, and pharmacokinetics. It is known that biphosphonates bind strongly to hydroxyapatite crystals at the sites of increased bone turnover preferentially and inhibit the formation, aggregation, and dissolution of the crystals.They also may inhibit osteoclast function directly, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation.
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