product information
(4-Amino-1-hydroxy-1-phosphono-butyl)phosphonic acid
CAS number: 66376-36-1
Groups: All Chemicals
Information:
IUPAC Name: (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid

CAS Number: 66376-36-1

Chemical Formula: C4H13NO7P2

Synonyms: 121268-17-5, 1yhm, (4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid, (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid, 4-Amino-1-hydroxybutane-1,1-diphosphonate, (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid), 4-Amino-1-hydroxybutylidene-1,1-bisphosphonate, 4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid), (4-Amino-1-hydroxybutylidene)bisphosphonic acid, (4-Amino-1-hydroxybutylidene)diphosphonic acid, (4-azanyl-1-hydroxy-1-phosphono-butyl)phosphonic acid, 66376-36-1, Acide alendronique [INN-French], Acido alendronico [INN-Spanish], Acidum alendronicum [INN-Latin], AHD, AIDS112217, AIDS-112217, alendronate, ALENDRONATE SODIUM, ALENDRONIC ACID, Alendronic acid [BAN:INN], Alendronic acid (INN), Alendronic acid [INN:BAN], Arendal, bisphosphonate, 65, C07752, C4H13NO7P2, CHEBI:2567, CID2088, D07119, DB00630, HSCI1_000337, LS-106421, MK 217, NCGC00096054-01, NCGC00096054-03, NCGC00096054-04, Oprea1_422906, Phosphonic acid, (4-amino-1-hydroxybutylidene)bis, Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, SPECTRUM1505166, T0501-8630

Product Info: Alendronic acid salts belong to the class of medications called bisphosphonates which binds to the hydroxyapatite in bone and act as a inhibitor of the resorption of bone for the treatment of osteitis deformans, postmenopausal osteoporosis, and hypercalcemia related to malignancy. It is a white crystalline powder; insoluble in water. Chemically, it is described as (4-amino-1-hydroxybutylidene) bisphosphonic acid. It is administered orally. Complexed with technetium 99m, it is a radiopharmaceutical used in bone imaging.

Biphosphonate, a salt, ester, or anion of a dimer of phosphonic acid (diphosphonic acid), inhibits bone resorption as a sodium salt and complexed with technetium Tc 99m for bone imaging. The monophosphonates are not active. Biphosphonates are used in disorders affecting the skeleton such as osteoporosis, metastatic disease, and Paget's disease. While bisphosphonates are analogues of endogenous pyrophosphate structurally, they are characterized by a P-C-P bond, the linking oxygen is replaced with a carbon, which is resistant to enzymatic and chemical hydrolysis. General structure is

Side chains are responsible for chemical-physicla properties, mechanism of resorption, and pharmacokinetics. It is known that biphosphonates bind strongly to hydroxyapatite crystals at the sites of increased bone turnover preferentially and inhibit the formation, aggregation, and dissolution of the crystals.They also may inhibit osteoclast function directly, promotion of osteoclast apoptosis, and interference with osteoblast-mediated osteoclast activation.
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